6.Sezona počinje sa emitovanjem 27.septembra 2009.
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This is the first season not to feature Edie Britt (Nicollette Sheridan) as part of the principal cast, having been with the show since its inception until May 17, 2009. Dave Williams (Neal McDonough) and Jackson Braddock (Gale Harold) will not be returning, either.
It is noted that the four protagonists - Susan Mayer (Teri Hatcher), Lynette Scavo (Felicity Huffman), Bree Van de Kamp (Marcia Cross), and Gabrielle Solis (Eva Longoria Parker) - and the series' narrator, Mary Alice Young (Brenda Strong), are all expected to return as regular castmembers next season given that they were contracted for the whole show's run. New Housewife Katherine Mayfair (Dana Delany) is also expected to return, as she has been contracted for at least three seasons.
Kathryn Joosten is expected to either retain her recurring role as Karen McCluskey, join the principal cast, or join Roberta McCluskey (Lily Tomlin) in a possible Desperate Housewives spin-off.
Julie Mayer (Andrea Bowen) and Karl Mayer (Richard Burgi) are expected to return in guest-starring roles, or re-join the principal cast.
Actress Maiara Walsh is joining the regular cast in the role of Ana Solis, Carlos Solis's teenage niece, who moves onto Wisteria Lane with the Solis family, and comes into conflict with Gabrielle.
In the last five minutes of the season finale of season five a couple was married. It is known from the season five finale that Mike Delfino is the groom, although it is not known whether Susan, Katherine or someone else is the bride.
Based on previous history, we expect the show will begin casting any regular or major recurring roles for the start of season 6 sometime next week (June 15-19).
Orson Hodge (Kyle MacLachlan) is planning to quit Desperate Housewives now that he is a father because he is finding the commute from New York City to the Desperate Housewives set in Los Angeles very difficult.